�Low levels of LDL cholesterol as well as high levels are associated with cancer in patients with type 2 diabetes, found a prospective cohort study promulgated in CMAJ.
Researchers from the Hong Kong Institute of Diabetes and Obesity, the Li Ka Shing Institute of Health Sciences and The Chinese University of Hong Kong conducted a work of 6107 Chinese patients with type 2 diabetes and base a V-shaped risk congress between LDL cholesterol and cancer in patients non receiving lipid-lowering medicine therapy.
"LDL cholesterol levels below 2.80 mmol/L and levels of at least 3.90 mmol/L were both associated with markedly grand risk of cancer among patients world Health Organization did non use statins," state Dr. Juliana Chan and coauthors.
The study excluded people on statins as statins obscured the association 'tween LDL cholesterin and all-site cancer.
Increasing data suggests an association between type 2 diabetes and an elevated risk of cancer the Crab, including breast, colorectal, pancreatic and liver cancers. An elevated jeopardy of crab in patients with low LDL was linked to cancers of digestive variety meat and peritoneum, genital and urinary variety meat, lymphatic and blood tissues as well as other areas. Patients with an LDL cholesterol level above 3.80 mmol/L had heightened risks of oral, digestive, os, skin, connector tissue, breast and other cancers.
Regarding clinical implications, the authors suggest "the use of these levels as peril markers crataegus oxycantha help clinicians to evaluate their patients more in full and so to forbid premature deaths in patients who have high risk."
They call for re-analysis of information from clinical trials to confirm or refute these findings.
In a related commentary, Drs. Frank Hu and Eric Ding of Harvard School of Public Health say confounding factors such as indication for the use of goods and services of statins, lifestyle and socioeconomic condition must be considered when looking at the association of high levels of LDL cholesterol and the risk of cancer.
"Low serum cholesterin is commonly observed in individuals with ill health (e.g. cancer patients) and those with unhealthy lifestyle characteristics such as smoking and heavy boozing," states Hu.
About CMAJ (Canadian Medical Association Journal)
CMAJ is the ahead health sciences journal in Canada. CMAJ is a general medical journal publication original research and review articles, commentaries and editorials, practice updates, an arts and ideas section and health news. Published continuously since 1911, new issues are uploaded on hTTP://www.cmaj.ca every second Monday at 4:30 p.m. EST/EDT. http://www.cmaj.ca contains the complete editorial contents of CMAJ, supplemented by a variety of interactive features and additional content.
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Thursday, 4 September 2008
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